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placebo-controlled trials, the incidences of abdominal pain, diarrhea, and flatulence were 19%, 31%, and 74% respectively in 1255 patients treated with Precose 50-300 mg t. Because Precose given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose, it may increase the potential for hypoglycemia. The increased gastrointestinal tract symptoms in patients treated with Precose are a manifestation of the mechanism of action of Precose and are related to the presence of undigested carbohydrate in the lower GI tract. Oral glucose (dextrose), whose absorption is not inhibited by Precose, should be used instead of sucrose (cane sugar) in the treatment of mild to moderate hypoglycemia. , treatment-emergent elevations of AST and/or ALT at any level of severity were similar between Precose-treated patients and placebo-treated patients (p ≥ 0. controlled clinical studies of Precose in patients with type 2 diabetes mellitus, reductions in glycosylated hemoglobin levels were similar in Caucasians (n=478) and African-Americans (n=167), with a trend toward a better response in Latinos (n=132).

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